<i>“We’re Seeking Relevance”</i>: Qualitative Perspectives on the Impact of Learning Analytics on Teaching and Learning

Whilst a significant body of learning analytics research tends to focus on impact from the perspective of usability or improved learning outcomes, this paper proposes an approach based on Affordance Theory to describe awareness and intention as a bridge between usability and impact. 10 educators at 3 European institutions participated in detailed interviews on the affordances they perceive in using learning analytics to support practice in education. Evidence illuminates connections between an educator’s epistemic beliefs about learning and the purpose of education, their perception of threats or resources in delivering a successful learning experience, and the types of data they would consider as evidence in recognising or regulating learning. This evidence can support the learning analytics community in considering the proximity to the student, the role of the educator, and their personal belief structure in developing robust analytics tools that educators may be more likely to use

Systematic review of the safety of medication use in inpatient, outpatient and primary care settings in the Gulf Cooperation Council countries

Background Errors in medication use are a patient safety concern globally, with different regions reporting differing error rates, causes of errors and proposed solutions. The objectives of this review were to identify, summarise, review and evaluate published studies on medication errors, drug related problems and adverse drug events in the Gulf Cooperation Council (GCC) countries. Methods A systematic review was carried out using six databases, searching for literature published between January 1990 and August 2016. Research articles focussing on medication errors, drug related problems or adverse drug events within different healthcare settings in the GCC were included. Results Of 2094 records screened, 54 studies met our inclusion criteria. Kuwait was the only GCC country with no studies included. Prescribing errors were reported to be as high as 91% of a sample of primary care prescriptions analysed in one study. Of drug-related admissions evaluated in the emergency department the most common reason was patient non-compliance. In the inpatient care setting, a study of review of patient charts and medication orders identified prescribing errors in 7% of medication orders, another reported prescribing errors present in 56% of medication orders. The majority of drug related problems identified in inpatient paediatric wards were judged to be preventable. Adverse drug events were reported to occur in 8.5–16.9 per 100 admissions with up to 30% judged preventable, with occurrence being highest in the intensive care unit. Dosing errors were common in inpatient, outpatient and primary care settings. Omission of the administered dose as well as omission of prescribed medication at medication reconciliation were common. Studies of pharmacists’ interventions in clinical practice reported a varying level of acceptance, ranging from 53% to 98% of pharmacists’ recommendations. Conclusions Studies of medication errors, drug related problems and adverse drug events are increasing in the GCC. However, variation in methods, definitions and denominators preclude calculation of an overall error rate. Research with more robust methodologies and longer follow up periods is now required.Peer reviewe

Iris extramedullary hematopoiesis in choroidal melanoma

PURPOSE: Extramedullary hematopoiesis (EMH) usually occurs in patients with loss of bone marrow hematopoietic function, and in a vast majority of cases, it involves the liver, the spleen, or the lymph nodes. We report EMH in the iris of patients enucleated for choroidal melanoma (CM). METHODS: We report a series of three patients with CM, two treated with primary enucleation and one with secondary enucleation. RESULTS: Histopathology revealed EMH in the iris of all patients. CONCLUSION: EMH of the iris can be associated with CM in the absence of any hematological or systemic disorders. To the best of our knowledge, our work is the first report of this abnormal histopathological finding

Scaling smallholder tree cover restoration across the tropics

Restoring tree cover in tropical countries has the potential to benefit millions of smallholders through improvements in income and environmental services. However, despite their dominant landholding shares in many countries, smallholders' role in restoration has not been addressed in prior global or pan-tropical restoration studies. We fill this lacuna by using global spatial data on trees and people, national indicators of enabling conditions, and micro-level expert information. We find that by 2050, low-cost restoration is feasible within 280, 200, and 60 million hectares of tropical croplands, pasturelands, and degraded forestlands, respectively. Such restoration could affect 210 million people in croplands, 59 million people in pasturelands and 22 million people in degraded forestlands. This predominance of low-cost restoration opportunity in populated agricultural lands has not been revealed by prior analyses of tree cover restoration potential. In countries with low-cost tropical restoration potential, smallholdings comprise a significant proportion of agricultural lands in Asia (∼76 %) and Africa (∼60 %) but not the Americas (∼3%). Thus, while the Americas account for approximately half of 21st century tropical deforestation, smallholder-based reforestation may play a larger role in efforts to reverse recent forest loss in Asia and Africa than in the Americas. Furthermore, our analyses show that countries with low-cost restoration potential largely lack policy commitments or smallholder supportive institutional and market conditions. Discussions among practitioners and researchers suggest that four principles - partnering with farmers and prioritizing their preferences, reducing uncertainty, strengthening markets, and mobilizing innovative financing - can help scale smallholder-driven restoration in the face of these challenges

Safety aspects of infliximab in inflammatory bowel disease patients - A retrospective cohort study in 100 patients of a German University Hospital

Background: Infliximab, a chimeric anti-tumour necrosis factor monoclonal antibody with potent anti-inflammatory effects, represents an effective treatment option in patients with severe inflammatory bowel disease (IBD). Serious side-effects of such an immunomodulating therapy are speculated and therefore we reviewed our clinical experience in a retrospective safety study looking upon a single cohort of 100 IBD patients from a large German University Hospital. Methods: 100 patients with severe Crohn's disease (n = 92), ulcerative colitis (n = 7) or indeterminate colitis (n = 1) treated with infliximab (5 mg/kg) from January 2000 to December 2003 were retrospectively analysed for acute and subacute adverse events by chart review. Results: Overall, infliximab therapy was generally well tolerated. No fatal complications, malignancies, autoimmune diseases, neurologic or cardiovascular complications were observed in the cohort during the study period. Overall, adverse events were observed in 10 patients: 2 patients showed an acute infusion reaction, 1 patient a serum sickness-like reaction, in 4 patients a bacterial or viral infection occurred, in 1 patient pancytopenia and 2 patients developed surgical complications. Only 6 patients with adverse events required admission to hospital. A case of tuberculosis after infliximab was not found. The lack of adverse side-effects was associated with young median age and infrequent comorbidities of the cohort. Conclusion: Regarding its strong immunomodulating capacity, infliximab appears to be an efficient and relatively safe therapeutic option for patients with severe IBD. However, the use of infliximab requires careful screening and close patient monitoring to identify patients at risk and the infrequent, but sometimes serious complications of infliximab. Copyright (C) 2004 S. Karger AG, Basel

Making if-then plans counteracts learned non-use in stroke patients: A proof-of-principle study

Background: After stroke, the learned non-use of a paretic arm is a major obstacle to the improvement of hand function. / Objective: We examined whether patients with a central paresis could profit from applying the self-regulation strategy of making if-then plans that specify situational triggers to using the paretic arm. / Method: Seventeen stroke patients with a mild to moderate hand paresis were asked to perform a Simon task which is commonly used to study the enhanced executive control needed when there is a mismatch between stimulus (e.g., color) and response (e.g., location) features. We examined whether patients with hemiparesis would be able to reduce the Simon effect (i.e., responding slower to mismatched as compared to matched stimulus and response features) by creating new stimulus-response associations via if-then plans. / Results: A significant Simon effect was observed in both the affected and the non-affected arm for control trials. However, there was no longer a significant Simon effect for the critical trials prepared by forming if-then plans. This led to a significant stimulus×compatibility interaction effect for the affected arm and a marginally significant interaction effect for the nonaffected arm. Making if-then plans was effective for eliminating or at least reducing the Simon effect for the affected and the non-affected arm, respectively. / Conclusion: This observation opens a potential new route to improving stroke rehabilitation. If-then plans may qualify as a viable strategy to overcome the learned non-use of the affected arm. Further research is now required to develop and test therapeutic measures based on this proof-of-principle

The Floodwater Depth Estimation Tool (FwDET v2.0) for improved remote sensing analysis of coastal flooding

Remote sensing analysis is routinely used to map flooding extent either retrospectively or in near-real time. For flood emergency response, remote-sensing-based flood mapping is highly valuable as it can offer continued observational information about the flood extent over large geographical domains. Information about the floodwater depth across the inundated domain is important for damage assessment, rescue, and prioritizing of relief resource allocation, but cannot be readily estimated from remote sensing analysis. The Floodwater Depth Estimation Tool (FwDET) was developed to augment remote sensing analysis by calculating water depth based solely on an inundation map with an associated digital elevation model (DEM). The tool was shown to be accurate and was used in flood response activations by the Global Flood Partnership. Here we present a new version of the tool, FwDET v2.0, which enables water depth estimation for coastal flooding. FwDET v2.0 features a new flood boundary identification scheme which accounts for the lack of confinement of coastal flood domains at the shoreline. A new algorithm is used to calculate the local floodwater elevation for each cell, which improves the tool\u27s runtime by a factor of 15 and alleviates inaccurate local boundary assignment across permanent water bodies. FwDET v2.0 is evaluated against physically based hydrodynamic simulations in both riverine and coastal case studies. The results show good correspondence, with an average difference of 0.18 and 0.31 m for the coastal (using a 1 m DEM) and riverine (using a 10 m DEM) case studies, respectively. A FwDET v2.0 application of using remote-sensing-derived flood maps is presented for three case studies. These case studies showcase FwDET v2.0 ability to efficiently provide a synoptic assessment of floodwater. Limitations include challenges in obtaining high-resolution DEMs and increases in uncertainty when applied for highly fragmented flood inundation domains

The Case for a New Frontiers–Class Uranus Orbiter: System Science at an Underexplored and Unique World with a Mid-scale Mission

Current knowledge of the Uranian system is limited to observations from the flyby of Voyager 2 and limited remote observations. However, Uranus remains a highly compelling scientific target due to the unique properties of many aspects of the planet itself and its system. Future exploration of Uranus must focus on cross-disciplinary science that spans the range of research areas from the planet’s interior, atmosphere, and magnetosphere to the its rings and satellites, as well as the interactions between them. Detailed study of Uranus by an orbiter is crucial not only for valuable insights into the formation and evolution of our solar system but also for providing ground truths for the understanding of exoplanets. As such, exploration of Uranus will not only enhance our understanding of the ice giant planets themselves but also extend to planetary dynamics throughout our solar system and beyond. The timeliness of exploring Uranus is great, as the community hopes to return in time to image unseen portions of the satellites and magnetospheric configurations. This urgency motivates evaluation of what science can be achieved with a lower-cost, potentially faster-turnaround mission, such as a New Frontiers–class orbiter mission. This paper outlines the scientific case for and the technological and design considerations that must be addressed by future studies to enable a New Frontiers–class Uranus orbiter with balanced cross-disciplinary science objectives. In particular, studies that trade scientific scope and instrumentation and operational capabilities against simpler and cheaper options must be fundamental to the mission formulation

Looking For Disoriented Chiral Condensates From Pion Distributions

We suggest two methods for the detection of the formation of disoriented chiral condensates in heavy ion collisions. We show that the variance in the number of charged pions (in a suitable range of momentum space) provides a signature for the observation of a disoriented chiral condensate. The signal should be observable even if multiple domains of D$\chi$C form provided the average number of pions per domain is significantly larger than unity. The variance of the number charged pions alone provides a signal which can be used even if the number of neutral pions cannot be measured in a given detector. On the other hand, the probability distribution in $R$, the proportion of neutral pions to all pions emitted in heavy ion collisions in certain kinematic regions, has been suggested as a signal of a disoriented chiral condensate. Here we note that the signature can be greatly enhanced by making suitable cuts in the data. In particular, we consider reducing the data set such that the $k$ pions with lowest $p_T$ are all neutral. We find that, given such cuts, can be substantially different from 1/3. For example, for a single D$\chi$C domain without contamination due to incoherently emitted pions, is 3/5 given the pion with lowest $p_T$ is neutral, and 5/7 given the two pions with lowest $p_T$ are both neutral, {\it etc.}. The effects of multi-domain D$\chi$C formation and noise due to incoherent pion emission can be systematically incorporated. Potential applications to experiments and their limitations are briefly discussed.Comment: 16 pages in REVTeX, 7 figures. Combined and updated version of nucl-th/9903029 and nucl-th/9904074. Accepted by Phys. Rev.